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COBRA therapy

One of the first studies that showed a positive effect of early and aggressive treatment was the COBRA trial (Dutch acronym for combination therapy in RA). In this trial, it was shown that COBRA therapy is better than sulphasalazine monotherapy in suppression of disease activity and radiologic progression of rheumatoid arthritis, with less side effects and lower costs. Furthermore, the delay in radiologic progression persisted up to 5 years.

In a more recent study, the BeSt-study, COBRA therapy was compared with three other treatment strategies, including the combination of high-dose methotrexate and infliximab. This study showed COBRA therapy to be equivalent to high-dose methotrexate and infliximab in effectively decreasing disease activity and joint damage.

In 2005, the VU University Medical Center and the Jan van Breemen Institute started with the implementation of COBRA therapy in clinical practice.  Because of the complexity of the treatment schedule, a patient information booklet and this website were made.

The driving force behind COBRA therapy is Professor Maarten Boers:

[to be completed with: interview/photo]

 

 
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